FSH Beyond Fertility

FSH LH : FSH ratio

Patient A was a 30-year-old white woman with a longstanding history of primary amenorrhea and infertility. By age 18 the patient had neither menstruated nor demonstrated evidence of normal breast development. At that time she was given oral contraceptives for four cycles and responded with normal vaginal bleeding. Laboratory evaluation at age 18 demonstrated a serum FSH (follicle-stimulating ho...

Ovulation, fertility and prenatal mortality in heifers treated with PMSG or porcine FSH.

Ovulation rate, fertilization rate and prenatal mortality were studied in yearling beef heifers treated with PMSG or FSH and in non-treated controls. Oestrus was synchronized in 50% of the animals in each treatment with an oral progestagen. The gonadotrophin injections were given during the normal oestrous cycle or during the progestagen-administration period. All heifers were inseminated 6 to ...

Moving beyond convenient assumptions on fertility, mortality and migration

Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond

Germline development in vivo is dependent on the environment formed by somatic cells and the differentiation cues they provide; hence, the impact of local factors is highly relevant to the production of sperm. Knowledge of how somatic and germline cells interact is central to achieving biomedical goals relating to restoring, preserving or restricting fertility in humans. This review discusses t...

Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.

OBJECTIVE To assess the pharmacogenetic potential of FSH for infertility treatment. DESIGN Review of the literature and genomic databases. METHODS Single-nucleotide polymorphism (SNP) assessed: rs6166 (c.2039A>G, p.N680S), rs6165 (c.919A>G, p.T307A), rs1394205 (c.-29G>A) in FSHR, and rs10835638 (c.-211G>T) in FSHB. Literature search via PubMed. Blast analysis of genomic information availabl...